With the yardages (150yds and in) that you mentioned and the velocities of the 300mag i'd probably recommend a bonded bullet for sure like the Nosler Accubond or something similar. If your going out to 300yds and beyond I think a standard cup and core would be fine but probably wouldn't be a good choice at close range from the 300mag. As for weight I personally like to shoot light for caliber bullets so if deer is the only thing you're hunting i'd probably go with the 150gr especially in a bonded bullet. Good luck! Mike