I agree with RR, the .22-250 is on the "hot side" for cat and fox, especially for the short ranges at which they are taken when called. It's a great coyote round, and very satisfying when running out long on colony varmints, but a little much horsepower for short work on fox or cats. I'm not one to condone anyone calling fox or cats if they aren't saving hides. Coyote hunting without fur harvesting is a different game - coyotes cause far worse livestock and wildlife depredation impact than fox or cat, so coyotes can and should be hunted to help balance the ecosystem. But if a guy is hunting fox or cat, I consider it wasteful if the hides aren't kept and sold. If you don't want to go to the trouble of selling for yourself, find a local furharvester and give the hides to them.

H4895 will run fine under 50grn pills in .22-250. H380, H3031, W760, and IMR4064 are other good options if you don't find a happy load for 4895. H380 is kind of the go-to powder for most folks. I've tended to load a lot more 4895, 3031, and 4064 especially, because I run it primarily in .30-06 and have a lot on hand.