Not much information on the shot gun so think you have made up you mind before posting this.
One thiung I would make real sure of is if the wolf is going to like the 50gr load of powder. I think you will have a problem there and need to step it up to 75 or 80 gr's even.
Now if the shot gun had threaded interchangeble choke tube barrel and was a pump gun I would go with that with a rifled choke and rifled slugs.
I use a 20 ga Reminton slugger in 20ga in SE Michigan. Have cane to like it as well as any high calber rifle I use in the UP.
I also own Muzzle loaders and find they are fussy with the amount of powder and projectile used.
Yes a slug gun can be fussy but not nearly so bad.
Al