I travel for a living, usually get between 100-150 hotel nights in a year. I almost NEVER leave anything in my hotel room when I'll be gone for anything longer than a trip to supper or the gym. Even then, most often I have everything in my vehicle.

I put an underseat rifle vault in my company truck. Convinced the company it would protect my business sensitive information and company IP to put it in, so they even paid for it. Ain't cheap, but I know it's a lot more secure than my hotel room.

My mother and some friends were in Houston on a trip this winter, apparently it was a common scheme going on, but drug runners would buddy up with hotel attendants to hide stuff in rooms, grab some sleep, and rob patrons. Her and her friends' bags were stolen while they were at supper one evening, nobody broke in, but someone entered their room with a key. Wasn't a master key, it was a dedicated single room key, coded for their particular room. Mom got her bag back, didn't even look like they had opened it, and her pistol was still inside. One of the friends' computer bag and jewelry bag were not recovered yet, doubtful they will be. The attendant was arrested on charges for aiding the theft, as the front desk video showed him keying 3 cards when they checked in, setting one aside, then only giving them two cards. There wasn't video of who took the card, but the attendant is on camera at the front desk during the time when the door lock record shows an entry to the room, so they had a partner. The attendant was the supervising shift manager who had several years on staff there, so it wasn't just some lacky on the job who was bouncing in and out just for this hit.

All comes down to situational awareness. Where you park, where you eat, where you stay, what you label on your car, etc - it all plays into how likely you are to be a target.