I don't often comment on old posts, but in this case I'll make an exception.
More often than not I'm packing multiple guns while hunting deer, usually either my scoped S&W Model 460 or T/C Encore handgun for long range shooting and an open sighted 41 Magnum Ruger Blackhawk for close range or finishing shots. Heck, I've even carried three at once: the Encore for >150 yard shots, the 41 Mag for <30 yard shots, and the 460 for anything in between. And yes, that was as cumbersome as it sounds. Of course, the only game I intend to shoot while deer hunting is a deer, or maybe a coyote if the opportunity arises. I wouldn't, for instance, pack my 22 pistol for squirrels if I'm hunting deer.