I used to have a 22-250 years ago. You're right about that sucker being loud. I wish I still had it - it would stack bullets on top of each other at 100 yards, even with me shooting.
This build is going to be more of a target/practice rig. You've seen the potent handguns I shoot. Needless to say feeding them gets expensive after a while. I've done the math, and I can reload it for far more cheaply than my other Encore handgun chamberings. Maybe it'll be a fair bit quieter than most of them, too.