I'm not reallly sure what you're talking about. I've used red dot sights before and I even have the TR25. That's a nice little compact setup. In fact I also have the S&W15 .22LR and I removed the sights and have a Buckmark red dot on it.
Once you have the dot sighted in you shoot with both eyes open. As long as the dot is on the target when the round goes off you will hit it. Your eye does not have to be in perfect alignment with the scope as it would with the open sights or a tubular rifle scope.