Jerry if you were to ask what cartridge did I kill the most deer with, I would have to say it was a toss up between the .243 and the .270. Both great time proven whitetail rounds. But, although I haven't shot too many deer with it, my current favorite deer cartridge is the 7mm-08. I have one in a Browning A-bolt Micro Hunter that is a joy to carry, shoots 'lights out' and has plenty of KE to drop the biggest whitetail.