About 10 years or so ago the choice would have been easy for me. I absolutely hated the 7mm Rem Mag and thought the 30-06 was the end all of cartridges. However they actually have 7mm bullets now that hold up to the velocities of the 7mm Rem Mag and perform very well on game. Both are great cartridges. Both will do the job on almost anything in North America. Flip a coin and you win either way. If you already have a 308 Win or a 270Win I would get the 7mm Rem Mag.