I bought a .300 Weatherby Vanguard about 5 years ago. My only regret is that I didn't buy it 40 years ago. It has fast become my favorite rifle.
My .257 Ackley has been my favorite medium size game rifle for about 35 years. If I didn't have it, I would buy a .257 Weatherby in a heartbeat.
Like muzzlestuffer posted, Weatherby ammo is expensive. I only shoot my handloaded ammo in all of my guns. Loading the same bullets, it only costs me about $0.10 per round more to load for my .300 Wby over a .30-06, because of the extra powder in the Bee.