Usually would expect that, but not always. I had an improperly aligned Ruger Vaquero once that shot incredibly well, even though you could visibly tell looking down the bore that it wasn't aligned right. Not surprisingly, that particular Vaquero was very poorly timed as well. Numbers matched, but it REALLY seemed like that cylinder was never meant for that revolver! But it shot really well.

Just trouble shooting though. My mentality would be that it's a symptom of a problem, regardless of what the problem is, and my mind would turn me inside out every time I saw it in the safe let alone took it out to shoot it.