A bit of late input. Not much new from other posts.

This is a wildcat cartridge that caught on. I think that this cartridge was originally named the "22 Varminter". I have shot one for many years. I have loaded bullets weighing from as light as 30 gr. to as heavy as 60 gr. with good results. My favorite load is made with a 55 gr. bullet.

In general the muzzle velocities, even from factory loads, will run around 3500-3700 fps. At these ultra high velocities the life of a barrel tends to be comparitively short. But unless you shoot a ton, the barrel should last a "lifetime".

My opinion .... it is not a medium game rifle, such as for deer sized game. At 22 cal. may be illegal for deer hunting in some states. For sure one can kill medium sized game with this cartridge and one of the heavier bullets it does well with, say a 55 gr. Nosler Partition .... but in my book, not a wise choice.

It is a fine varmint rifle .... coyotes, fox, bobcat and such .... but way beyond a wise use on a rabbit or squirrel that you intend to put in the pot. Hit one square-on with a 22.250 and you would not have much left to cook !!