As far as repeat loads with Pyrodex and other subs.
It does depend on your load and how tight it is.
I laugh when I hear about these guys that insist that they need thier load to be beaten in with a hammer to make thier load shoot. That is nonsense even for the smokless guys. All you are doing is damaging a perfectly good projectile.
Tight is good but there comes a point where "tight is not right". I like a snug fit. One that seats firmly with minimal effort.
With that said the loads I usually worked up in the past with subs Like Pyrodex or 777 could usually go up to 4 loads without any spit patch or swabbing. It was usually getting tight by the 4th shot needing some assistance moreso getting the 4th one down. By the 5th shot I was either swabbing or done for the day.