I use Varget in quite a few different loads, so I have a fair amount of it on-hand. It's probably what I'll start with. I've used BL-C(2) with 60 gr HPs, but wasn't generally impressed with the results. Then got into a cheap source (back then) for M855 ball and stopped loading for the ARs.

I've been loading 50 gr V-Maxes for three bolt guns using Varget for coyotes and prairie dogs in both .223 and .22-250 and have lots of bullets and powder on hand for those two loads, but nothing that would be suitable for big-game hunting with either. I don't think the .22-250 is going to stabilize a heavier bullet well, so working up a load with a heavier bullet in the .223 may become my winter project.