There are two schools of thought here . Since I shoot an Endeavor Encore and have been using it for several years I thought I might pass on some things. In order to drop the deer on the spot I use a 250 grain BONDED Shock Wave with 140 grains of Blackhorn. This must be placed just over the top of the heart from broadside. For complete penetration and a good blood trail a 275 Bloodline brass bullet in the same spot or a 250 grain Deep Curl or even a barnes all copper with the large open hollow point will work. Personally I prefer dropping them on the spot to following a blood trail. Bullet placement is the key.