Yes, I have a Z600 on my 6.5 Grendel AR. It actually works quite well. The easiest approach would be to go to the Zeiss website. Look up the Rapid Z calculator and enter in your pertinent info. It will give you the yardages for the stadia lines at an optimal power setting (if you want the ranges to correlate to the 3,4,5 and 6 marked lines, just adjust the power as recommended). For example, on my set-up, if I set it at 6.5X my ranges are 299@3, 395@4, 499@5 and 600@6. In other words, they correspond to the markings already on the reticle. If not, see what the yardages are at high power, print it off and head to the range to verify. On mine (3-9 x 40), when I go up to 9X, the ranges change to 273@3, 345@4, 425@5 and 505@6. Also, changing variables such as elevation, inclination, bullet / load BC or weight will changes your numbers. Whatever you end up with, you must verify at the range.