If buying another gun is what this is about, then the 25/06 seems like the one. It fills the gap between your 22/250 and the 7 mag. I agree that the .280 (as well as the .270) are great calibers, but If I already had a 7 mag, I would just load that with a bullet/load and use it. A 139-150 gr. 7mm would be great for antelope and lots of other stuff.