Actually I would never sight any rifle in at 25 yards.With such a close sight in even a very small difference in the height of the scope above the bore will make a significant difference at longer ranges.As well a small error on actual zero will be ten times as much at 250 yards as it is at 25 yards.If the windage was actually 1/4" out at 25 yards it would be 2-1/2" out at 250yards.Also the trajectory will vary a fair bit with the load as an example a 300win mag shooting a 150gr bullet will have a much different trajectory than the same gun shooting a 200gr bullet. Sight in your rifle to be 2" high at 100 yards but shoot it at 200 yards and 300 yards to see where the point of impact really is.Ballistic tables are fine in theory but can often have significant error due to variances in actual velocities,varying ballistic co-efficients of bullets and the scope height above the bore.