Go to loose powder, then you can vary the powder charge until you find what works...No need to let pellets dictate what bullets you use...Here is what I got with a buddy's Optima when I sighted her in with Goex FFF and .429-.430 Hornady 300gr XTPs and a Harvester plain green sabot...
I have sighted in 5 different inlines with this same bullet/sabot combo with good results...On all of them I ended up with 80-85grs of FFF Goex...