It can be done. BUT!!, if you are not familiar with hogs and their demeanor and body build, DO NOT DO IT!!!!!!!!!!!!! I have killed hundreds of hogs with many weapons from .22LR to 338 Win. Mag, pistols and bow. And just recently a knife.
I have shot them from the side on feeding hogs straight in the ear and they were DRT. Shot them from the side/behind to just behind the ear and they were DRT. Have shot them in the lowerbase of the skull from the ground and had them DRT. But it has to be a brain shot with a 22LR. Your rifle has to be dead nuts on to be able to this and shoot a high velocity solid that groups the best you can get. Do not shoot target ammo for they are not fast enough for the needed deep penetration of the skull. And as Yankee Doodle said, good track shoes are a necessity if things go FUBAR!!!!!!!!!!!