I just bought an X-Bolt Hunter in 280 and I love it. It weighs a good pound less than my Model 70's. Bruse is right...ammo can be a pain to find and the variety isn't the greatest. If you don't reload I'd take more than you need.

As far as I know, Browning and TC (Venture) are the only 2 current makers that chamber anything in a 280. Gunbroker is a good place to start looking.

Edit: I guess Remington does too.