Usually take lung or high lung shots but if I have my .243 in my hands and a deer is within 50 yards and a neck shot is presented then it puts them down every time...Looking straight at me, I aim just below the throat patch, quartering to, lower neck angled behind the opposite shoulder...
Nothing unethical about taking a shot you know you can make, heck I've killed hundreds of squirrels at these ranges with head shots...
I've killed a couple of hundred deer with that .243...I know what it can do and what I can do...