I can tell you, i have shot one deer with a 300gr hardcast with a pretty good sized metplat. He walked right under me and i put it right between his shoulders aiming down and slightly away. Blew straight through his spine and into the dirt under him and never retrieved the bullet.

He tumbled down the hill a few yards. Probably dead before he stopped sliding.

The 400gr+ cayugad casts a bit soft would just flatten them.