Kind of depends. I mostly hunt public land with a fair amount of pressue on it, so I suspect the deer smell some human odor frequently. I set my stands up keeping the prevailing winds in mind. If the winds aren't right in the morning, I will alter my plans. Once I'm up there though, I'm staying. No. 1, if the winds are shifting, they could shift again. No. 2, I take steps to minimize my odor, so, though less than ideal, I rely on those.