It does matter where you're from (where you hunt) when deciding when to shoot.
I'm from NJ but live now in SoCal and believe me there is a difference !!!
No matter where you're from or where you hunt however; when you first lay eyes on your quarry and you say to yourself, "that's a shooter"...........that's what I use as my measuring stick.
A big deer in one part of the country, is small in another part of the country.