I am getting into this a bit late but I do want to touch on a couple of points.
It is my opinion that the boys in the speed gets er done crowd are guys that want a rifle and bullet combo that will be capable of hitting the target at long range. They also want enough whomp at that range to hopefully get the job done. They for the most part have scopes that they adjust for a certain range and they want as little hold over as possible.
The Conical boys are the kind of guys that for the most part shoot open sights and for the most part stay around 100 yards of less. They use them because they feel that they do a better job than the PRB. Their rifles for the most part have fixed sights and the hold over is too much to estimate past 125 yards.

I am in a slightly different crowd. I believe in big heavy conicals. I trust MY paper patched Lee 500 S&W bullets to sink deep. I have seen enough of them hit game now that I am starting to prove reliability. First off this bullet has a wide meplat. The wide meplat hits like a freight train on steroids. I don't know of any ML bullet that provides a meplat as wide as the Lee 500 S&W bullet.
I custom pour these bullets to a specific hardness and the load is tuned to the rifle. Quality control is kept to +-.5 grains. If you want to see a shocker weigh some of your store bought bullets and compare them for weight.
I have seen them enter a big mule deer buck at the shoulder breaking the shoulder and exiting out through the hind quarter at 117 yards. I have seen them plow through deer and antelope form all angles and I have NEVER seen a recovered bullet.

Next the hold over. Unless a guy is using a scope that is built to adjust like a sniper scope your going to have to hold over or use some kind of built in multiple crosshair model to keep from having to hold over. Traditional Iron sights just can't handle long range. The traditional front sight is too thick to aim small. Rear buck horn sights are just a shot in the dark past 100 yards maybe less.
Sabots have been popular to help speed things up to the point that hold over is minimized. But it is still there.

Again I am in a different crowd. I use a front sight that is a BPCR style front sight. It is designed for long range. My rear sight is a Lyman 57 SML. It is field adjustable. So if my range finder says 100 I set the sight at 100 and hold dead on. If the range finder says 135 I set it and hold dead on. If the range finder says 175 I set it for 175 and hold dead on. No hold over or hold under.
I don't need to shoot a super fast bullet for a antelope, or try to set up for elk. I shoot one load for everything. So far it has never let me down. Ron