I' ll presume you are using an in-line, 1:28 twist, .50 caliber, and hunting in the same state as I am-- and using 100 grains of Pyrodex RS or Triple 7. That is a lot of presuming.

In that case, there are three bullets that are worth a try-- and just stick with what your gun shoots the best:

prbullet.com 300 grain Dead Center (.44 ca / .50 cal sabot)

Buffalo SSB 325 grain sabot

Powerbelt 348 grain