I carry Glocks and won't buy a defensive gun with a manual safety because that is one more thing I have to do in a defensive situtation and one more potential problem. I carry with one in the chamber because if I have to use it, more then likely I won't have time to chamber a round. If you are not comfortable yet with one in the chamber, carry your gun for a week or more without one and see if your worries are founded. If you need your gun for defense, you may not have time or both hands to chamber around.