New string and cable + Suddenly shooting bad = String/cable creep.

If you would check your brace height, axle to axle length and cam timing, you' ll likely find each one is out of spec. Your draw weight is likely at least 5 pounds less than you set it for. You need to get the string and cable twisted up and put back in spec. Everything will line right out again.

You have to expect creep when you change out your strings and cables. Every time. Always shoot at least 150 arrows through the bow to settle the rigging, twist everything back up to their correct lengths, and THEN do your final tuning and sighting in. Fine tuning before settling the rigging is simply a waste of time.