Has anyone shot 100 grains of Pyrodex pellets and then 100 grains of Pyrodex loose powder out of the same gun with the same bullet to see if the POI is similar or the same?

The reason I ask this, is I hunt with Pyrodex pellets, and I love them. I have no desire to deal with loose powder in the field. The one thing I don't like about the pellets is the cost. They are a fair bit more than loose powder, so it gets expensive shooting at the range. Now that I see the loose powder on clearance here in store, I'm wondering if I should buy a pound.

Now I know it will obviously shoot different in each gun, and I have to try it in my gun to make sure, but I wondered if in general it has the same POI. I'm thinking I could sight the gun in using the loose powder and practice at the range with loose powder, then switch to the pellets to hunt. However, if they are going to shoot totally different, I'd rather no waste my money on the pound of loose powder.