In a traditional rifle with open sights, you'll never know the difference between where a .50 or a .54 hits with 100grs of powder...

My .54 is 2 inches high at 50 yards, dead on at 75 and about 2 inches low at 100...I wouldn't shoot at a game animal past 125 yards because the ball loses it's kinectic energy pretty fast past 125 yards...I've done quite a bit of competitive shooting past 125 and I'll tell you doping the wind and bullet drop gets mighty tricky with a round ball gun once you get past 125...