I cast a 525 grain bullet for my 50 caliber MZ's. The bullet is devastating. My longest shot on an elk was 145 yards. He went maybe 30 yards after the shot. And it was all he could do to go 30 or so yards. He went sick from the moment he was hit. The bullet is devastating on deer.
I also shot all the sabots and all the expensive MZ bullets in those sabots. Then I went back to conicals. Guys always complain about the performance they get out of the $1 a piece bullets. But how often have you heard anyone complain about a 525 grain conical not knocking the snot out of a deer??
Practice is not a problem with a conical that you pour. The cost is so low that you can shoot all day. I would argue that practice is too costly with Barnes bullets, not the conicals you pour.
I do not find trajectory to be a problem. But I use an LRF when I hunt in areas where shots can be over 150 yards. No big adjustment is needed until you get to 150 yards(on big game).
I always think it is funny when someone says a MZ is only good to 100 yards with a heavy conical. When they openly know that buffalo hunters shot BP cartridges(and BP rifles) to extreme ranges, with great efficacy. I firmly believe an MZ is fully capable of the same. You just have to practice, and know what you are doing. Tom.