The answer to your question depends on a few more factors.
1) How sensitive to recoil are you?
2) How experienced in high powered rifles are you?
3) What will you be going after for hunting, or will this be a target rifle?

The AR 10 will get the job done well, across the board, but you'll lose a little accuracy at longer ranges in comparison to a bolt gun.
However, it is quite refreshing to have an instant follow up shot available without having to manually rack a round...