They can do a trick on deer. I load 300 grain hornady 45 cal XTP bullets in my 20 ga loads using CCS sabots and have shot many deer with that load but have recovered only one slug so far. It was a 4 point buck quartering toward me at 60 yards. The bullet entered the right shoulder going through the shoulder blade traveling the full length of the deer hitting the left leg just below the ball joint shattering the bone then stopping in the flesh after that. Mushrooms nicely and weighed in at 292.7 grains. Muzzle velocity is a little over 1500 fps.