I would load the 210 Nosler Partition as an all around bullet for this type of hunting with a .338 WM, or a similar weight Nosler AccruBond or other brands of tough bullet. I have had the 210 give nice exit holes in bull elk and it shoots flat enough to make it effective on other game. I have shot elk and mulies with this bullet, but have not shot an antelope with it. I doubt that any tough bullet from a .338 would waste much meat on a tiny antelope.