Probably..............just sight it in at 300yds be about 8 in high at 200 and around 14 low at 400 .....the bullet will have plenty of poop to get the job done U just need to get it in the kill zone...on an antelope I have no idea how big it is but on a mulie U got 8/10 inches to hit and on a elk around 22 in just find a good set of ballistics for the cartrige U are shootin and study it and then go and shoot it alot and in different conditions!!!