I saw a piebald doe last archery season out of range.I' m holding off shooting anything in that area this year til I see if she' s still around.If she comes around this year again and is in range,she' s going down.
Years ago I shot a 9 pointer the local farmer called patches.He had patches of white hair on both back legs.Not a true piebald in my book,but just the same it didn' t effect my deer hunting success and if I get this doe doubt if it will have any effect either.
My dad killed a piebald doe a few years ago too and he never saw any negative effects from shooting her.
Go for it if the opportunity presents itself!