I " let em eat" !!! I have a 280, 7mag & 30/06 (yep what one will do the others will do, I can only have one woman so I at least have a few different guns!) I sight them all in 3" high at 100 and since I typically shoot light bullets, they typically are " on" in the 250-300yd range. But since getting a Sako/Lazzeroni Warbird, I havent the need for maxing out my other guns anymore. I only hunt with the Warbird and the 280 anymore and then the 280 I only shoot while in the woods. I am cosidering re-sighting it to be only an inch, inch-half high at 100 as a result. My Warbird shoots a 30cal 130 Xbullet at 3900fps, with 3" high at 100 it is dead on at 400 and about 7" low at 500.
LOL my grandfathers old 35 Marlin he left to me isnt scoped, so why bother? If it was scoped (he made me promise I wouldnt because to him, " Its a saddle gun, not built for a scope" !) I would probably have it about 3" high at 100 as well. (However I' m glad I aint stuck with its garden hose trajectory!)
Whack em where they stand!

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RA