As a reloader, there are some rounds that don't completely fill the case with powder after the bullet is seated, and you'll hear the powder if you shake the round a little.
Theoretically, it hurts consistency in accuracy, as there can be a slight variance in the combustion pattern if the powder is spread differently from shot to shot, but I'm not a good enough shooter to detect the difference.
I know that in my 300WSM, my favorite load is slightly less than "totally full", so I have a small air pocket in every round. If I maxed out the load, I'd have a compressed load, IE the bullet would compact the powder when I seat the bullet, which, in theory, promotes better accuracy.
Is there a difference? I don't honestly know.
Would I worry about it for hunting purposes? Nope.
I think that the difference in accuracy wouldn't be readily detectable until you're reaching out past 300-400 yards, which in a .243 is at or past the range which I would take a shot at any animal.
If you're shooting competitions at extreme range, you may want to reconsider your load, but for yote hunting inside 200, I think the difference is pretty negligible.
You be the judge.