Depends on the gun and bullet...If shooting out to 300 yards you don't want to sight dead on at 100 yards anyway...

I sight mine in 2 1/2 inches high at 100 yards and I'm hitting about 6 inches low at 300...She is 2 inches high at 200 and dead on at 250...This is with standard 100gr CoreLokts...

If you want another good, long range bullet, try the Federal Premium 85gr Sierra GameKing HPBT...Sight in 2 1/2 high at 100 yards and you should be about 3 inches low at 300...

I can't stress enough that this needs to be verified in your own personal rifle...Through the years, I've killed deer with around a dozen different factory .243 loadings...I've seen some, when sighted in 2 1/2 high at 100 yards be as much as 6 inches low at 250...