A lot of common sense and some time at the range will answer most of these questions. I once read where Elmer Keith killed some deer with a 45lc at some outrageous ranges. Anything is possible. Common sense says it's not probable. I'm not a fan of monster mags but for those that are that's wonderful for them. I do have magnums and hunt with them every year myself as well as other standard calibers. I say the man that shoots the most comes home with more meat.