It can be done safe, but shots a running deer can be unethical if the conditions aren't perfect. I know that the running deer debate is a big one and I am not trying to start it up. But I would be willin to bet that a lot of deer get wounded from those 2nd , 3rd and 4th shots. An as fast as some people are crackin them off I know they cant be settlin there sights on vitals.