I don't see an advantage other than ease of use. 100 grains of loose powder, Pyrodex should be real close to the same performance as 100 grains of Pyrodex pelets. With loose powder you can tailor you load to a specific amount. I use 90 grains of loose powder for my pet load, works just fine. That would be 3 30 grain pelets and even more expensive in the long run.
Later,
Marcial