I prefer hunting from a stand, but I have a lot of areas I hunt where there are no good trees to set up or there's too many lower trees like hollies that block a good view from a stand. I have shot most of my mature bucks from a tree, but then again, I've only started hunting from blinds the past two seasons.
BTW - I unfortunately find it a whole lot easier to comfortably fall asleep in my Summit than the chairs in my blinds w/o a head rest.
Mike