the others gave great advice....

i use a 200yd zero on my 22-250 only because i cant find a range that has a 250yd target....

if you look at the last trajectory ridge runner posted, you can see that with a 250yd zero, your never more than about 3" off out to 300yds...aim center mass and your killing whatever you shot if your shot is true...i do like to know the extremes and adjust accordingly...ive missed many groundhogs shooting for the head at 100yds...makes me feel pretty dumb when im killing them at 200-350yds but missing at 100 lol...but i know thats why...

good luck! ya picked a nice caliber...i love mine...