I sight my 22-250 in at .7" high at a hundred. It's dead on at 200 yards with that particular load. And It makes it comparable to my other hunting rifles and loads so I'm not doing much brain work when it comes to hold overs at longer ranges. A preprogrammed brain is better than gadgets when it comes to hunting, especially when time is critical on making a shot.
Plus a 22-250 is one of the flatter calibers out there you don't need to sight it in very high to obtain max point blank range for shooting. I've noticed if I stick around a 200yard sight in, it tends to more consistant 300-500 yard kills on varmits. Most times if your crosshairs are not on hair you shooting beyond 350 yards with a 22-250. So thats when knowing your rifles trajectory is crucial beyond that range. Especially on a 9" body of a coyote. I only average around 2 out of 5 kills on running coyotes up to 400 yards so if your like me and like driving around shooting yotes you'll want simplicity vs complicated scopes and gadgets.
I have a straight 6x weaver on my Ruger no1 22-250. Same sight picture everytime also elminates need for time ranging and sight picture in rushed shots. I preferred not to make my varmit rifle too complicated, i'm not using it as a bench rest rifle. Pairie dogs is a different game all together once you go beyond 300yds you have to be able to see the lil guys.
good luck