22-250 for Ghogs, I'd say a good starting point would be the 55 gr Ballistic tip or Vmax. Both will fly flat with extreme terminal performance for as far as you can shoot.

38 gr of H380 is what put the 22-250 on the map. My buddy loads 3031 in his, can't tell you what the charge is though. Nosler's 5'th shows 39.5 gr of H380 as the fastest load and best accuracy.