Depends on where you hunt at, for me I hunt in thicker areas and enjoy getting up close and personal with the deer. I personally have never taken a deer past 45 yards and have taken them as close as 4 or 5 yards, so I never sight in my black powder for anything past 50 yards really. If I actually use my .45 cal that has scope on it I could aim up just a little for longer shots. I have taken some practice shots out to 100yrds just to see where I hit, and I am a couple inches low.
Both my .50's are sighted in at 50 yards both iron sights also. My Hawkens is nasty and really surprised me, wanna try it out after hunting season at really long distance just for fun on paper.