With arrow rest as low as possible to the hand (with clearance for the vanes), you set your nock point accordingly to bareshaft tuning, BH tuning, or even paper tuning.

You can raise a rest up, way up and compensate with nocking point but at the expense of noise and poor flight.

Best scenerio is like a crossbow. where the nocking point is dead center between cams and pressure point on the prod is dead center. But because you have to hold a compound, or longbow, and the arrow can't go thru your hand, you have to compensate for this.