The average shooter would have a hard time keeping 3 shots inside 4 inches at 250 yards in the hunting field with a bolt action .270 and 3x9 power scope...Much less with a muzzleloader...
Ballistic tables are references and should not be substituted for load development and experience...You simple can't take a 50 yard target, look at a table and then expect to hit the vitals of a deer out to 250 yards...Too many variables...